Reduce Colorectal Cancer Risk with Calcium and Vitamin D
A recent research indicates that calcium and vitamin D nutrients function together, not separately, to minimize the risk of colorectal cancer.
Maria V. Grau, M.D., of the Dartmouth Medical School in Lebanon, N.H., and her colleagues looked at data on 803 people who participated in the Calcium Polyp Prevention Research, a randomized trial that found a beneficial effect of calcium supplementation to prevent colorectal cancer from recurring.
The new study found that calcium supplements decreased the risk of recurrence only in individuals with baseline levels of vitamin D above the median (29.1 ng/mL). Similarly, serum vitamin D levels have been associated with reduced adenoma recurrence only in individuals taking calcium supplements.
These findings "provide a strong indication that vitamin D and calcium have a joint antineoplastic effect in the large bowel," write the authors, adding that "further investigation is needed to understand the mechanistic basis of the vitamin D/calcium interaction and to clarify the amount of intake of each nutrient required for optimum protective effect."