Posts by Arthur Allen
Say It Ain’t So, President-Elect O
Some science bloggers are alarmed by predictions in the news that President-elect Barack Obama intends to appoint Robert F. Kennedy Jr. as head of the Environmental Protection Agency.
After eight years in which the Bush administration trashed science to favor a political agenda, these blogger are saying that Kennedy would be a most injudicious choice, since he’s just as liable to politicize science as the other guys did, only from the left. More …
Foreclosure Epidemics
Subprime mortgages have ruined banks and insurance companies and brought the global economy to its knees. Now it looks like they’re also causing the spread of deadly West Nile disease.
In a weird new wrinkle in the story of the exploding mortgage crisis, the housing market in Bakersfield, Calif., was tied to a 276 percent increase in the number of West Nile virus cases, according to the November issue of the scientific journal, Emerging Infectious Diseases.
It’s easy to find correlations between seemingly unrelated events; epidemiological journals are full of stuff like this which doesn’t mean a thing. For example, as ice cream consumption increases, so do drownings. But it’s not because ice cream causes drowning.
In this case, though, the cause-and-effect link is pretty clear. Delinquent mortgages in Bakersfield and the surrounding community caused people to abandon their houses, and mosquitoes carrying West Nile virus bred in their untended swimming pools. The resulting outbreak is a epidemiologists’ textbook case of the unintended consequences of economic turmoil. It’s not the first such example, and undoubtedly won’t be the last before the crisis ends.
“We’ve had problems with West Nile in California since 2004, but in 2007 the housing market really went south and it resulted in a lot of neglected swimming pools,” said lead author William K. Reisen, an entomologist at the University of California, Davis. “They’ve always had problems with homeowner neglect of pools. But all of a sudden, it went through the roof.”
There were 140 confirmed human cases of West Nile virus in the Bakersfield area in 2007, the largest outbreak in California, and the worst mosquito-born encephalitis virus outbreak in Kern County since 1952. At least two patients — one, a 96-year-old woman — died of the disease, which can also cause brain damage.
The outbreak spread to several other counties and led Gov. Arnold Schwarzenegger to hold a news conference and release $6.2 million in emergency mosquito abatement funds.
West Nile virus outbreaks intensified in other parts of California this summer, in particular in Los Angeles. This could well be related to the swelling foreclosures in that area, Reisen said.
Insect-borne microorganisms thrive in times of economic crisis and dislocation. For example, mosquito-borne dengue fever has surged in the growing cities of Asia and Latin America in the past decade; as people move into urban areas that lack running water, they store water in tanks that are perfect breeding grounds for mosquitoes like Aedes aegypti, the leading dengue vector.
Count the Kern County West Nile outbreak in that category. “What’s worrisome is that most U.S. mosquito abatement districts are funded by property taxes,” said Reisen. “As their revenue falls, it’s going to be harder to keep up with the abandoned swimming pools.”
West Nile has spread gradually across the United States since the first cases were reported in 1999 in New York City. It’s carried by several different species of mosquitoes and can infect many birds and mammals — from crows and chickens to cats and horses. In different areas of the country, the epidemic has generally slowed after the virus kills off a large enough number of the birds that carry it from place to place. Only about one in 100 people exposed to the virus become ill; about three percent of those it sickens die from this disease.
No one in Kern County had anticipated the 2007 outbreak. Winter and spring rains were light, and the Kern River, which flows through Bakersfield and sometimes leaves pools of water where mosquitoes can breed, was dry. In fact, water was so short that it changed the bird ecology of the region, resulting in an expansion of house sparrow flocks. Unlike other bird populations in the area, most of the sparrows lacked protective immunity to West Nile virus.
The county Mosquito and Vector Control District conducted an aerial survey of the town that showed an extensive number of green or neglected pools, “most of which were producing mosquitoes,” according to the article in Emerging Infectious Diseases.
“The likely reasons for neglected pools,” reported the journal, which is published by the Centers for Disease Control, “are the adjustable rate mortgage and associated housing crises in Kern County and throughout California, which have led to increased house sales and abandonments.” Kern County suffered a 300 percent increase in delinquencies in the spring quarter of 2007 compared with the same period in 2006.
As chlorine-based chemicals deteriorated in the abandoned pools, “invasive algal blooms created green swimming pools that were exploited rapidly by urban mosquitoes, thereby establishing a myriad of larval habitats within suburban neighborhoods.”
By California law, properties with swimming pools must be surrounded by six-foot-high fences, and so it has been difficult for mosquito control agents to enter foreclosed properties. “They can’t just go breaking the doors down,” said Reisen. “It’s kind of a mystery how to get access to these properties.”
The major carrier of West Nile during the 2007 outbreak was the common mosquito Culex pipiens. But by this year, Culex tarsalis, a more efficient West Nile carrier that typically colonizes rural areas, had moved into some of them.
That said, no human cases had been reported in 2008 as of Oct. 23, though the disease continued to infect mosquitoes and kill birds and horses. Kern County officials have been vigilant in spraying the abandoned pools or stocking them with larva-eating fish.
Then too, West Nile outbreaks are sporadic, and seem to depend on complex factors in the virus’ hosts. High temperatures, raising the viral load of mosquitoes, are one such factor; a die-off of the crow population, causing the virus to run out of hosts, can also play a role.
The Bakersfield story presents another such factor: the crashing of American dreams.
Predatory Practices
The wolf is an intelligent, handsome creature and, for many visitors to Alaska, an integral part of the state’s wild appeal. Wolves live in complex social structures, mate for life and don’t attack humans — it’s easy to see in them the family resemblance to mankind’s best friend.
That’s More…
FDA Steps Up Salmonella Screening
The FDA has intensified its checks on produce coming into the United States since the Salmonella stpaul outbreak began, and has put 17 firms on notice that they need to watch contamination of their produce. More …
The American Way: ‘Bigger, Stronger, Faster’
When Mike, Chris and Mark Bell, were striving to become champion iron pumpers in Poughkeepsie, N.Y., the brothers never dreamed that Arnold Schwarzenegger, Hulk Hogan and their other idols were juiced. Steroids were for commies –like Dolph Lundgren in Rocky IV. Rocky himself was clean and sober. He chopped wood to get buff.
But, as they got older, the Bells learned the dirty little secret: their heroes were on ‘roids. The Bells would have to take them too, if they wanted to compete. Years later, Mark—who went by “Mad Dog” when he wrestled for World Wresting Entertainment, the WWE, and “Smelly” Mike – who can bench press 700 pounds– are still using the stuff.
Chris, the middle brother, tried steroids for a few months, stopped and decided to make a movie about them instead. His documentary film, “Bigger, Stronger, Faster: The Side Effects of Being American,” is a hilarious, poignant and thought-provoking look at the hypocritical culture of competition.
“I was brought up to believe that cheaters never prosper,” he narrates, over footage of President George W. Bush speaking against steroid use — though his Texas Rangers used them. “But in America, they always prosper.”
With the Olympics beginning Friday and millions of kids primed to watch their U.S. heroes compete with the world, Bell sadly reflected on what he learned about the clandestine doping that goes on beyond the noble striving for national glory. Bell, 35, spent three years working on the film, which incorporates dozens of interviews and other footage.
“I used to think the Olympics had the best drug testing, but it’s a big façade,” he said in a phone interview. The Balco scandal — in which a San Francisco steroid producer provided hundreds of baseball players with hard-to-trace steroid shots — revealed some of the tricks that trainers use to evade testing. Olympic committees have done little to keep pace with the cheaters, Bell said. “You can skirt the rules on hormones. There’s no test for human-growth hormone. There’s an improved test for Epo [which increases oxygen in the blood], but it won’t be ready for the Olympics.”
“I don’t want to be one of those conspiracy-theory guys, but there are a lot of people juicing,” he said. “You’re never going to have a 100-percent clean Olympics. It’s sad. Kids look up to these people.”
News accounts indicate a certain vigilance against doping Olympic athletes. But the history of such scandals, Bell suggests, is that only the unlucky get caught. During the 1988 games, Jamaican sprinter Ben Johnson lost his gold medal in the 100 meters for steroid use. Carl Lewis, to whom the gold was awarded, had also tested for banned substances in his blood during training. Rather than disqualify him, according to Bell’s well-documented account, the U.S. Olympic Committee changed the rules.
Anabolic steroids became controlled substances in 1990, and are banned by most professional sports associations, but it’s an open secret that you can’t be the best bodybuilder, weight lifter or home run hitter (or swimmer?) without them. And so, people cheat.
Bell’s film, which incorporates his own interviews, news footage and cartoons in a hilarious gallop through the issue, makes two main points about steroid use. The first is that steroids, as bodybuilder Gregg Valentino puts it during the film, “are as American as apple pie” — that the American drive to win trumps the American sense of fairness every time. This, Bell is saying, is what really bothers Congress, which held more hearings about steroids in 2006 than it did on the war in Iraq. Steroids aren’t nearly as dangerous as tobacco, alcohol or dozens of other legal substances, but their use reveals something ugly about America, and not just its athletics industry.
“There’s this assumption that steroids kill, but no one can find the bodies,” Bell said. Valentino has biceps that look like a python swallowing a pig. But Bell shrugs. “Some people just want big arms. If people want to look like freaks, why can’t they? Is it any worse than piercing strange parts of yourself?”
Or as Valentino himself puts it, “I wanted to be big. I couldn’t get taller, so I got wider.”
Bell may be underplaying the potential side effects of steroid use. While it’s true that the scientific evidence of liver damage and hyper-aggressive “roid rage” is mixed, longterm steroid use definitely raises your bloodpressure and unhealthy cholesterol levels, shrinks your testicles and gives you “bitch tits,” in the ineffable phrase of the Bell brothers. It probably also stunts the growth of teenagers. Bell, to be sure, isn’t exactly promoting steroid use. “I know people who’ve been abused by steroids. If you think one minute my brothers are fine and not screwed up in the heads from fact they rely on steroids … when you rely on a drug to do anything, you’re looking for trouble.”
Too, juicing goes against the American sense of fair play. But if Tiger Woods can get laser eye surgery, and students can take legal speed to ace tests, why shouldn’t athletes improve their torque with chemistry? Bell manages to make even Barry Bonds look sympathetic, as the slugger tells the press, “All of you have lied. How would you like it if there were asterisks by your names?”
“Bigger, Stronger, Faster” united Chris Bell’s two obsessions: movies and body-building. A music video he made at community college got him from Poughkeepsie to film school at the University of Southern California. While studying there, he worked as a bouncer, lifted at the famous Gold’s Gym in Venice Beach,and later wrote for the WWE. A short film about tobacco addiction got the attention of the producers of “Farenheit 911″ and “Bowling for Columbine.”
The film achieves something unusual — it manages to convey respect and affection toward subjects whose foibles are hilarious. The narration makes it happen. Bell is schlubby in a Michael Moore kind of way, but unlike Moore, he’s sincere, because the pain is personal. A regular guy in gym clothes and a backwards baseball cap, he depicts America’s identity confusion through his own family’s struggle with obesity, drug use and obfuscation.
In a section about how the wildly under-regulated dietary-supplements industry uses juiced lifters to deceptively sell its products, Bell hires some Mexican guys to make a supplement in his kitchen. “It was all perfectly legal — except for the illegal aliens.”
His brothers are symbolic stand-ins for the conflict. “Smelly’’ is emotionally stable, a loving father who coaches high school football. “Mad Dog” is bipolar, has tried to kill himself, hates his job, drinks too much and takes drugs. They’re both lifetime steroid users.
Ultimately, in this film, we see steroids as just another substance that Americans use to fill emptiness. Bell’s mother is shocked to hear how dependent on them her boys are. “Why did our boys feel like they were not good enough?” she asks. “Mad Dog” responds that he can’t handle a life in which he’s just OK. “I need to attain greatness,” he says. “I know there’s something in here that the rest of the world needs to know about.”
“In my experience, bodybuilders are like little kids in a gorilla suit,” Bell told me. “They pack on armor so nobody can hurt them. When I was lifting weights, I thought I’d be the coolest kids in school if I could bench press the most. It felt good.
“But I found out from the film,” Bell said, “that I’m a much better filmmaker than I am power lifter.”
Of Course Ivins Might Have Been Innocent
Which his lawyer says here. It wouldn’t be the first time the Feds had railroaded an innocent man. Hopefully we’ll learn more about the evidence soon.
Suicide May Clarify Anthrax Mystery
An Army scientist named Bruce Ivins committed suicide this week as the Feds were preparing to indict him for the October 2001 anthrax attacks, according to news reports Friday. If Ivins’ guilt in the attacks is confirmed, it would mean that the bioterror scare, which whipped the country into hysteria and in doing so helped pave the way for the invasion of Iraq, was generated by a self-interested American (assuming Ivins did it, and was acting alone).
Ivins, 62, had worked in the development of anthrax vaccines and therapeutic drugs at Fort Detrick, Maryland, with publications going back to 1984. He had participated in 14 published studies on anthrax since the 2001 attacks; his latest paperwill be published Tuesday in the journal Vaccine.
Investigators have long suspected that a government scientist or contractor was responsible for the anthrax mailings to Democratic senators and the news media, which killed five people and crippled the postal service. After initial suspicions of a link to al-Qaeda or other foreign terrorists failed to materialize, the FBI focused on a former colleague of Ivins named Steven Hatfill. Those suspicions also did not pan out, and the government earlier this year paid Hatfill more than $5 million for damaging his reputation.
If, as suspected, Ivins mailed the anthrax spore-laden letters to raise the alarm and generate more resources for bioterrorism defense, his attack can only be considered a dramatic success. Billions have poured into industry contracts and government work aimed at preventing such attacks in the future. Some have speculated that the anthrax mailings were not meant to kill, but only to show how possible it was to send deadly anthrax spores through the mail.
How Did FDA Get it Wrong on Tomatoes?
After announcing Wednesday that the “smoking jalapenno ” had been found on a farm in Mexico, witnesses at a hearing Thursday continued to dance around the key problem with the salmonella investigation, which we identified three weeks ago: early mistakes by the New Mexico department of health and the Centers for Disease Control doomed the investigation.
Members of Congress and their witnesses from the world of public health and the food industry spent most of the two days of hearings this week debating whether new FDA regulations were needed for tracing produce. There was also some snark exchanged over the fact that the food industry itself had lobbied for less stringent tracing requirements when Congress issued new food safety guidelines in 2002 as part of the bioterror legislation. At this week’s hearings, the industry called for the FDA to do more.
But there were occasional moments of clarity. “The real place where this started was the identification of tomatoes as the culprit at the CDC,” said Thomas Stenzel, president of the United Fresh Produce Association, at a hearing of the House Energy and Commerce subcommittee on oversight and investigations. While the FDA may have been slow and failed to release information fast enough, Stenzel said, its investigation into the contaminated produce was narrowed to tomatoes based on the CDC’s analysis. This in turn was based on early, apparently flawed epidemiological work done by New Mexico investigators on Navajo Indian reservations. “We didn’t make a mistake,” said an exasperated David Acheson, the FDA’s point man on the crisis. “Our investigation was based on what the states and the CDC told us.”
The culprit was narrowed early to tomatoes, but after more than 1,400 tomato samples had been tested, none turned up positive for Salmonella saintpaul. “The hearing today should be about the CDC and state public health departments,” noted John Shimkus (R-Ill.) the ranking GOP subcommittee member. “That’s where the system failed us.” It’s not a question of pointing fingers–New Mexico reportedly has a small, underfunded public health department, and even the best epidemiologists make mistakes. Tim Jones, state epidemiologist of Tennessee, noted that state public health budgets have sunk over the past decade, despite occasional surges of federal money spurred by scares such as anthrax or pandemic flu. But if the government is to learn anything from this problematic outbreak, which has now caused more than 1,300 cases of illness in 43 states, it ought to begin by looking in the right places.
Is Jindal Too Conservative for McCain?
Gov. Bobby Jindal of Louisiana is young, Southern and right-wing — a set of demographics that Sen. John McCain, the presumed Republican nominee, has sought to draw into his campaign. So why did Jindal last week take himself out of the running for the No. More…
FDA Bobbles, Minnesota Finds the Red Hot Pepper
Nice piece of reporting by the AP’s Lauran Neergaard about how shoe-leather Minnesota epidemiologists traced the contaminated jalapenos that seem to be responsible for the supposed tainted-tomato Salmonella outbreak. Alerted about an outbreak in late June in Minnesota, public health officials there interviewed the sick, traced the Salmonella Saintpaul to a particular restaurant, and used credit card receipts to see who had or had not gotten the jalapeno relish on their food, thereby confirming jalapenos as the prime suspect. Then they traced the jalapenos back to a farm in Mexico–where they found Salmonella on a pepper–and from there to a distributor in McAllen, Texas. It took about 10 days to do all this. Michael Osterholm, who has become a big-shot consultant in the bio-terror world, directed the Minnesota public health department for years and seems to have left behind a solid institution. The obvious question: Why were a handful of Minnesota scientists able to quickly resolve an outbreak that stumped the FDA and CDC for four months?
To be sure, no one is positive that all 1,100+ Salmonella Saintpaul infections are jalapeno-related, though there’s no concrete evidence of anything else. Meanwhile, the FDA continues to be accused of providing partial and confusing information about the scare, infuriating the produce industry, which has suffered hundreds of millions in losses.
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